Search results for "Hypothalamic–pituitary–thyroid axis"

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Hypothalamic-pituitary-thyroid axis in acromegaly

1983

To evaluate the hypothalamic-pituitary-thyroid axis in acromegaly, total and free thyroid hormones and TSH response to TRH were determined in 36 acromegalic patients. In 10 patients, rT3 and thyroxine binding globulin (TBG) were also assayed by radioimmunoassay. In 15 patients the TSH response to TRH was also studied after medical or surgical therapy of the acromegaly. In 34 patients total thyroid hormones were in the normal range whereas two patients had low serum levels of free thyroid hormones. Thirty-two of the acromegalic patients were euthyroid. However, only 43.7% of the euthyroid patients had a normal TSH response to TRH. Nine patients had a reduced TSH rise after TRH, whereas in 4 …

AdultMaleHypothalamo-Hypophyseal Systemendocrine systemmedicine.medical_specialtyendocrine system diseasesEndocrinology Diabetes and MetabolismThyroid GlandThyrotropinThyroid Function TestsThyroxine-binding globulinEndocrinologyTRH stimulation testInternal medicineAcromegalymedicineHumansEuthyroidThyrotropin-Releasing Hormonebiologybusiness.industryThyroidMiddle Agedmedicine.diseaseHypothalamic–pituitary–thyroid axisThyroxinemedicine.anatomical_structureEndocrinologyHypothalamusAcromegalybiology.proteinTriiodothyronineFemaleThyroid functionbusinesshormones hormone substitutes and hormone antagonistsJournal of Endocrinological Investigation
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Effects of resistance training on testosterone metabolism in younger and older men

2015

This study investigated the effects of resistance training (RT) on the metabolism of testosterone (T) in younger (n=5, 28±3yrs.) and older (n=8, 70±2yrs.) men. Experimental heavy resistance exercises (5×10RM leg presses) were performed before and after a 12-month of RT. No age differences were found in the production or metabolic clearance rate of T (determined by stable isotope dilution method), skeletal muscle androgen receptor content or serum LH concentrations due to acute or chronic RT. The T production capacity response to gonadotropin stimulation and the concentrations of the urinary T metabolites (androsterone and etiocholanolone) were lower in the older compared to younger men (p<0…

AdultMaleLuteinizing hormoneAgingmedicine.medical_specialtyta3111AndrosteroneBiochemistryMuscle hypertrophychemistry.chemical_compoundEndocrinologySex hormone-binding globulinInternal medicineEtiocholanoloneGeneticsmedicineHumansTestosteroneMuscle Skeletalta315ExerciseMolecular BiologyTestosteroneAgedEtiocholanoloneAndrosteronebiologyta1184Age FactorsResistance TrainingCell BiologyHypothalamic–pituitary–thyroid axisPatient Outcome AssessmentRenal EliminationAndrogen receptorEndocrinologychemistryReceptors AndrogenIsotope LabelingGnRHbiology.proteinLuteinizing hormoneHormonemedicine.drugExperimental Gerontology
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